Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury.

@article{Lai2008OverexpressionOT,
  title={Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury.},
  author={Zhong-fang Lai and Yu-Zhen Chen and Li-ping Feng and Xian-min Meng and Jin-feng Ding and Lai-yuan Wang and Jue Ye and Ping Li and Xiaoshu Cheng and Yasunori Kitamoto and Koshiro Monzen and Issei Komuro and Nobuo Sakaguchi and Shokei Kim-Mitsuyama},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 2},
  pages={H708-16}
}
TNNI3K is a new cardiac-specific MAP kinase whose gene is localized to 1p31.1 and that belongs to a tyrosine kinase-like branch in the kinase tree of the human genome. In the present study we investigated the role of TNNI3K in the cardiac myogenesis process and in the repair of ischemic injury. Pluripotent P19CL6 cells with or without transfection by pcDNA6-TNNI3K plasmid were used to induce differentiation into beating cardiomyocytes. TNNI3K promoted the differentiation process, judging from… CONTINUE READING
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