Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer

@inproceedings{Shin2012OverexpressionOS,
  title={Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer},
  author={Na Ri Shin and Eun Hui Jeong and Chang In Choi and Hyun Jung Moon and Chae H Kwon and In Sun Chu and Gwang Ha Kim and Tae Yong Jeon and Dae Hwan Kim and Jae Hyuk Lee and Do Youn Park},
  booktitle={BMC Cancer},
  year={2012}
}
Epithelial–mesenchymal transition (EMT) plays a significant role in tumor progression and invasion. Snail is a known regulator of EMT in various malignant tumors. This study investigated the role of Snail in gastric cancer. We examined the effects of silenced or overexpressed Snail using lenti-viral constructs in gastric cancer cells. Immunohistochemical analysis of tissue microarrays from 314 patients with gastric adenocarcinoma (GC) was used to determine Snail’s clinicopathological and… CONTINUE READING
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