Overexpression of Sigma Factor, ςB, Urges Staphylococcus aureus to Thicken the Cell Wall and to Resist β-Lactams

  title={Overexpression of Sigma Factor, ςB, Urges Staphylococcus aureus to Thicken the Cell Wall and to Resist $\beta$-Lactams},
  author={Kazuya Morikawa and Atsushi Maruyama and Yumiko Inose and Masato Higashide and Hideo Hayashi and Toshiko Ohta},
  journal={Biochemical and Biophysical Research Communications},
Abstract Whole genome sequence analysis revealed that Staphylococcus aureus is provided with only a few sigma factors, including the alternative sigma factor, ς B , which is thought to regulate some stress responses. Since the sig B knock-out mutant did not show remarkable phenotypic difference, we constructed the over expressed mutant to examine the role of the sig B. Electron microscopic observation revealed that the mutant showed a variety of cell sizes compared with the parent strain which… 

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