Overexpression of Sigma Factor, ςB, Urges Staphylococcus aureus to Thicken the Cell Wall and to Resist β-Lactams

  title={Overexpression of Sigma Factor, ςB, Urges Staphylococcus aureus to Thicken the Cell Wall and to Resist $\beta$-Lactams},
  author={K. Morikawa and A. Maruyama and Y. Inose and M. Higashide and H. Hayashi and T. Ohta},
  journal={Biochemical and Biophysical Research Communications},
Abstract Whole genome sequence analysis revealed that Staphylococcus aureus is provided with only a few sigma factors, including the alternative sigma factor, ς B , which is thought to regulate some stress responses. Since the sig B knock-out mutant did not show remarkable phenotypic difference, we constructed the over expressed mutant to examine the role of the sig B. Electron microscopic observation revealed that the mutant showed a variety of cell sizes compared with the parent strain which… Expand
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Themes and variations in prokaryotic cell division.
  • W. Margolin
  • Biology, Medicine
  • FEMS microbiology reviews
  • 2000
Although some cell division determinants such as FTSZ are present in a broad spectrum of prokaryotic species, the lack of FtsZ in some species and different profiles of cell division proteins in different families suggests that there are diverse mechanisms for regulating cell division. Expand