Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.

@article{Shang2019OverexpressionOS,
  title={Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.},
  author={Jinjie Shang and Lin Wu and Yanmei Yang and Yan Li and Zecheng Liu and Ying Huang},
  journal={Fungal genetics and biology : FG \& B},
  year={2019},
  volume={122},
  pages={
          11-20
        }
}
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References

SHOWING 1-10 OF 86 REFERENCES
Characterization of cis-elements in the Promoter of trz2 Encoding Schizosaccharomyces pombe Mitochondrial tRNA 3'-end Processing Enzyme.
TLDR
The results suggest that the low-level trz2 expression may arise from a low level of transcription caused by lack of a strong TATA box and the NRE.
Knockout of Drosophila RNase ZL impairs mitochondrial transcript processing, respiration and cell cycle progression
TLDR
Drosophila RNase ZL is implicates in a novel retrograde signaling pathway initiated by the damage in mitochondria and manifested in a cell cycle delay before the mitotic entry, suggesting a critical role for ROS.
Ectopic expression of mitochondria endonuclease Pnu1p from Schizosaccharomyces pombe induces cell death of the yeast.
TLDR
Although expression of human Bak in S. pombe was lethal, Pnu1p nuclease is not necessary for hBak-induced cell death, and ectopic expression of active Pnu 1p led to cell death with fragmentation of nuclear DNA, suggesting that the Pnu2p is possibly involved in a certain type of yeast cell death via DNA fragmentation.
The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial translational activator
TLDR
Ppr10 functions as a general mitochondrial translational activator, likely through interaction with mitochondrial mRNAs and mitochondrial translation initiation factor Mti2, and that Ppr10 requires Mpa1 association for stability and function.
Activation of the Iron Regulon by the Yeast Aft1/Aft2 Transcription Factors Depends on Mitochondrial but Not Cytosolic Iron-Sulfur Protein Biogenesis*
TLDR
Iron sensing by Aft1/Aft2 is not linked to the maturation of cytosolic/nuclear Fe-S proteins, but the mitochondrial inner membrane transporter Atm1 is important to transport the inhibitory signal.
The S. pombe mitochondrial transcriptome.
TLDR
This work uncovers the complexity of a fungal mitochondrial transcriptome and provides a framework for future studies of mitochondrial gene expression using S. pombe as a model system.
Schizosaccharomyces pombe Cells Deficient in Triacylglycerols Synthesis Undergo Apoptosis upon Entry into the Stationary Phase*
TLDR
This study found that two gene products (Plh1p and Dga1p) are responsible for the terminal step of TAG synthesis in the fission yeast Schizosaccharomyces pombe through two different mechanisms, and provides strong evidence suggesting that DAG, not sphingolipids, mediates fatty acids-induced lipoapoptosis in yeast.
Iron homeostasis in the fission yeast Schizosaccharomyces pombe
TLDR
These regulatory responses to variations in iron concentrations ensure that iron is present within cells for essential biochemical reactions, yet prevent the accumulation of iron or iron-using proteins to deleterious levels.
The fission yeast Schizosaccharomyces pombe has two distinct tRNase Z(L)s encoded by two different genes and differentially targeted to the nucleus and mitochondria.
TLDR
Evidence is provided for partitioning of tRNase Z function between two different proteins in S. pombe, although one cannot rule out specialized functions for each protein.
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