Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia.

  title={Overexpression of SUR2A generates a cardiac phenotype resistant to ischemia.},
  author={Qingyou Du and Sofija Jovanovi{\'c} and Allyson Kara Clelland and Andrey Sukhodub and Grant R. Budas and Karen Phelan and Victoria Murray-Tait and Lorraine Malone and Aleksandar Jovanovi{\'c}},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={20 8},
ATP-sensitive K+ (K(ATP)) channels are present in the sarcolemma of cardiac myocytes where they link membrane excitability with the cellular bioenergetic state. These channels are in vivo composed of Kir6.2, a pore-forming subunit, SUR2A, a regulatory subunit, and at least four accessory proteins. In the present study, real-time RT-PCR has demonstrated that of all six sarcolemmal K(ATP) channel-forming proteins, SUR2A was probably the least expressed protein. We have generated mice where the… CONTINUE READING


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