Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease.

@article{Massaad2009OverexpressionOS,
  title={Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease.},
  author={Cynthia A. Massaad and Taneasha M Washington and Robia G. Pautler and Eric Klann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 32},
  pages={
          13576-81
        }
}
Alzheimer's disease (AD) is a neurodegenerative disease characterized by impaired cognitive function and the deposition of extracellular amyloid plaques and intracellular tangles. Although the proximal cause of AD is not well understood, it is clear that amyloid-beta (Abeta) plays a critical role in AD pathology. Recent studies also implicate mitochondrial abnormalities in AD. We investigated this idea by crossing mice that overexpress mitochondrial superoxide dismutase (SOD-2) with the Tg2576… CONTINUE READING

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