Overexpression of SNX7 reduces Aβ production by enhancing lysosomal degradation of APP.

Abstract

Abnormal production of amyloid-β peptides (Aβ) by proteolytic processing of amyloid precursor protein (APP) is thought to be central to the pathogenesis of Alzheimer's disease (AD). Although many efforts have been made to investigate mechanisms that regulate APP processing, many details remain incompletely understood. Sorting nexins (SNXs) are a family of… (More)
DOI: 10.1016/j.bbrc.2017.10.127

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