Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma.

@article{Komatsu2009OverexpressionOS,
  title={Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma.},
  author={Shuhei Komatsu and Issei Imoto and Hitoshi Tsuda and Ken‐ichi Kozaki and Tomoki Muramatsu and Yutaka Shimada and Satoshi Aiko and Yutaka Yoshizumi and Daisuke Ichikawa and Eigo Otsuji and Johji Inazawa},
  journal={Carcinogenesis},
  year={2009},
  volume={30 7},
  pages={
          1139-46
        }
}
Although we have identified two putative targets, ATF3 and CENPF, for a frequently gained/amplified region around 1q32-q41 in esophageal squamous cell carcinoma (ESCC), it is possible that other amplification targets remain to be identified. In this study, we tested whether SET and MYND domain-containing protein 2 (SMYD2), located between those two genes and encoding a lysine methyltransferase for histone H3K36 and p53K370 that regulates transcription and inhibits transactivation activity… 

Overexpression of SMYD2 contributes to malignant outcome in gastric cancer

Findings suggest that SMYD2 has a crucial role in tumor cell proliferation by its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.

Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma

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Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.

YAP is a candidate oncogene for esophageal squamous cell carcinoma.

The results indicate that YAP is a putative oncogene in ESCC and it represents a potential diagnostic and therapeutic target.

SMYD2 promotes tumorigenesis and metastasis of lung adenocarcinoma through RPS7

The protein methyltransferase SET and MYND domain-containing protein 2 (SMYD2) is a transcriptional regulator that methylates histones and nonhistone proteins that might modulate tumorigenesis and metastasis mediated by RPS7 LUAD.

Positive Expression of SMYD2 is Associated with Poor Prognosis in Patients with Primary Hepatocellular Carcinoma

Findings provide evidences that positive expression of SMYD2 in HCC may be important in the acquisition of an aggressive phenotype, and it is an independent biomarker for poor prognosis of patients with HCC.

Overexpression of PBK/TOPK Contributes to Tumor Development and Poor Outcome of Esophageal Squamous Cell Carcinoma.

Findings suggest that PBK/TOPK plays a crucial role in tumor malignant potential through its overexpression in ESCC.

Overexpression of TRIM44 contributes to malignant outcome in gastric carcinoma

The findings suggest that TRIM44 plays a crucial role in tumor cell proliferation through its overexpression, and highlight its usefulness as a predictor and potential therapeutic target in gastric cancer.

TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer

Overexpression of the TRIM37 protein was detected in almost all GC cell lines and GC samples and was significantly correlated with lymphatic and venous invasion, advanced T-Stage, N- Stage, histology and high recurrence rate.
...

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