Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation.

@article{Visp1998OverexpressionOR,
  title={Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation.},
  author={St{\'e}phane Visp{\'e} and Christophe Cazaux and C Lesca and M. Defais},
  journal={Nucleic acids research},
  year={1998},
  volume={26 12},
  pages={2859-64}
}
Rad51 proteins share both structural and functional homologies with the bacterial recombinase RecA. The human Rad51 (HsRad51) is able to catalyse strand exchange between homologous DNA molecules in vitro . However the biological functions of Rad51 in mammals are largely unknown. In order to address this question, we have cloned hamster Rad51 cDNA and overexpressed the corresponding protein in CHO cells. We found that 2-3-fold overexpression of the protein stimulated the homologous recombination… CONTINUE READING

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