Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis

@article{Zhang2009OverexpressionOR,
  title={Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis},
  author={Keqiang Zhang and Shuya Hu and Jun Wu and Linling Chen and Jianming Lu and Xiaochen Wang and Xiyong Liu and Bingsen Zhou and Yun Yen},
  journal={Molecular Cancer},
  year={2009},
  volume={8},
  pages={11 - 11}
}
In addition to its essential role in ribonucleotide reduction, ribonucleotide reductase (RNR) small subunit, RRM2, has been known to play a critical role in determining tumor malignancy. Overexpression of RRM2 significantly enhances the invasive and metastatic potential of tumor. Angiogenesis is critical to tumor malignancy; it plays an essential role in tumor growth and metastasis. It is important to investigate whether the angiogenic potential of tumor is affected by RRM2. We examined the… CONTINUE READING

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