Overexpression of RACK1 Promotes Metastasis by Enhancing Epithelial-Mesenchymal Transition and Predicts Poor Prognosis in Human Glioma

@inproceedings{Lv2016OverexpressionOR,
  title={Overexpression of RACK1 Promotes Metastasis by Enhancing Epithelial-Mesenchymal Transition and Predicts Poor Prognosis in Human Glioma},
  author={Qiao-li Lv and Yuan-Tao Huang and Gui-hua Wang and Yan-Ling Liu and Jin Huang and Qiang Qu and Bao Cun Sun and Lei Hu and Lin Cheng and Shu-hui Chen and Hong-hao Zhou},
  booktitle={International journal of environmental research and public health},
  year={2016}
}
Emerging studies show that dysregulation of the receptor of activated protein kinase C1 (RACK1) plays a crucial role in tumorigenesis and progression of various cancers. However, the biological function and underlying mechanism of RACK1 in glioma remains poorly defined. Here, we found that RACK1 was significantly up-regulated in glioma tissues compared with normal brain tissues, being closely related to clinical stage of glioma both in mRNA and protein levels. Moreover, Kaplan-Meier analysis… CONTINUE READING

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Oncogene • 2015
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