Overexpression of Protein Phosphatase Non-receptor Type 11 (PTPN11) in Gastric Carcinomas

  title={Overexpression of Protein Phosphatase Non-receptor Type 11 (PTPN11) in Gastric Carcinomas},
  author={Jin Soo Kim and Ok Ran Shin and Hyung Keun Kim and Young Seok Cho and C. H. An and Keun Woo Lim and Sung Soo Kim},
  journal={Digestive Diseases and Sciences},
Tyrosine phosphorylation and dephosphorylation by protein tyrosine kinases and phosphatases (PTPs), respectively, play crucial roles in cellular signal transduction. Protein phosphatase non-receptor type 11 (PTPN11) is a positive signaling PTP that activates RAS and ERK signaling. Also, the PTPN11 binds with CagA of Helicobacter pylori in gastric epithelial cells. The aim of this study was to explore whether alteration of PTPN11 protein expression is a feature of gastric cancer cells. We… CONTINUE READING
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