Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root.

@article{Phelan2003OverexpressionOP,
  title={Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root.},
  author={Shelley Ann Phelan and Xin-Yu Wang and Pia Wallbrandt and Kristina Forsman-Semb and Beverly J. Paigen},
  journal={Free radical biology & medicine},
  year={2003},
  volume={35 9},
  pages={1110-20}
}
The mammalian 1-Cys peroxiredoxin (Prdx6) is a unique member of the peroxiredoxin family of proteins capable of protecting cells from metal-catalyzed oxidative damage. We recently identified Prdx6 as a candidate for the quantitative trait locus Ath1, a gene responsible for a difference in diet-induced atherosclerosis susceptibility in mice. To investigate the role of Prdx6 in atherosclerosis, we generated transgenic mice that overexpress the Prdx6 allele from the Ath1-resistant 129/SvJ strain… CONTINUE READING