Overexpression of PRAD1 in a mantle zone lymphoma patient with a t(11;22)(q13;q11) translocation.

@article{Komatsu1993OverexpressionOP,
  title={Overexpression of PRAD1 in a mantle zone lymphoma patient with a t(11;22)(q13;q11) translocation.},
  author={Hirokazu Komatsu and Kaori Yoshida and Masao Seto and Shinsuke Iida and Taro Aikawa and Ryuzo Ueda and Chikara Mikuni},
  journal={British journal of haematology},
  year={1993},
  volume={85 2},
  pages={427-9}
}
The PRAD1 gene identified from the chromosome band 11q13 region was previously demonstrated to be overexpressed in cell lines with t(11;14)(q13;q32) translocation and was suggested to be a candidate BCL-1 gene. We report here one case of mantle zone lymphoma with a t(11;22)(q13;q11), a variant translocation at the BCL-1 locus, having the PRAD1 overexpression. By analogy with the c-myc gene in Burkitt's lymphoma and the BCL-2 gene in follicular lymphoma, this case supports strongly the idea that… CONTINUE READING

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