Overexpression of PPARγ can down-regulate Skp2 expression in MDA-MB-231 breast tumor cells

  title={Overexpression of PPARγ can down-regulate Skp2 expression in MDA-MB-231 breast tumor cells},
  author={Jie Meng and Yun Min Ding and Aiguo Shen and Meijuan Yan and Fei He and Huoyan Ji and Lin Zou and Yonghua Liu and You Wang and Xiaowei Lu and Huimin Wang},
  journal={Molecular and Cellular Biochemistry},
Skp2 is frequent amplified and overexpressed in breast cancer, making it a potential molecular target for cancer therapy. The objective of this study was to examine the effect of PPARγ overexpression on Skp2 expression in breast cancer cell lines. First, we investigated the role of PPARγ and Skp2 in human breast cancer progression. Immunohistochemical analysis of 70 specimens on formalin-fixed paraffin sections was performed. Furthermore in vitro, Western blot analysis was used to study the… CONTINUE READING


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