Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity.

@article{Bosma2013OverexpressionOP,
  title={Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity.},
  author={Madeleen Bosma and Lauren M Sparks and Guido J. E. K. Hooiveld and Johanna A Jorgensen and Sander M. Houten and Patrick Schrauwen and Sander Kersten and Matthijs K C Hesselink},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1831 4},
  pages={844-52}
}
AIMS/HYPOTHESIS While lipid deposition in the skeletal muscle is considered to be involved in obesity-associated insulin resistance, neutral intramyocellular lipid (IMCL) accumulation per se does not necessarily induce insulin resistance. We previously demonstrated that overexpression of the lipid droplet coat protein perilipin 2 augments intramyocellular lipid content while improving insulin sensitivity. Another member of the perilipin family, perilipin 5 (PLIN5), is predominantly expressed in… CONTINUE READING

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Perilipin 5

  • K. Kuramoto, T. Okamura, +15 authors T. Osumi
  • a lipid droplet-binding protein, protects the…
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