Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma

@inproceedings{Xu2016OverexpressionOP,
  title={Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma},
  author={Meng Xu and Chartia Ching-Mei Cheung and Chit Chow and Samantha Wei-Man Lun and S K Cheung and K. D. Lo},
  booktitle={PloS one},
  year={2016}
}
BACKGROUND Nasopharyngeal carcinoma (NPC) is a peculiar Epstein Barr virus (EBV)-associated malignancy that is prevalent in South-East Asia. Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) isomerizes specific phosphorylated amino acid residues, which makes it an important regulator in cell survival and apoptosis. In this study, we investigated the contribution made by PIN1 in NPC tumorigenesis and PIN1's potential role as a therapeutic target. METHODS The expression of PIN1 was… CONTINUE READING
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