Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer

  title={Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer},
  author={S. Mukai and N. Oue and T. Oshima and T. Imai and Yohei Sekino and R. Honma and N. Sakamoto and K. Sentani and H. Kuniyasu and H. Egi and K. Tanabe and K. Yoshida and H. Ohdan and W. Yasui},
  journal={The Journal of Pathology},
  • S. Mukai, N. Oue, +11 authors W. Yasui
  • Published 2017
  • Biology, Medicine
  • The Journal of Pathology
  • Gastric cancer (GC) is one of the most common human cancers. Genes expressed only in cancer tissue, especially on the cell membrane, may be useful biomarkers for cancer diagnosis and therapeutics. In the present study, we focused on the PCDHB9 gene, which encodes the transmembrane protein protocadherin B9. Immunohistochemical analysis revealed that 62 (36%) of 173 GC cases were positive for protocadherin B9. Protocadherin B9 staining was mainly observed on the GC cell membrane. Expression of… CONTINUE READING
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