Overexpression of PAK1 Promotes Cell Survival in Inflammatory Bowel Diseases and Colitis-associated Cancer

@inproceedings{Khare2015OverexpressionOP,
  title={Overexpression of PAK1 Promotes Cell Survival in Inflammatory Bowel Diseases and Colitis-associated Cancer},
  author={Vineeta Khare and Kyle Dammann and Mario Asboth and Anita Krnjic and Manuela Jambrich and Christoph Gasch{\'e}},
  booktitle={Inflammatory bowel diseases},
  year={2015}
}
BACKGROUND Chronic gut inflammation predisposes to the development of colorectal cancer and increased mortality. Use of mesalamine (5-ASA) in the treatment of ulcerative colitis modulates the risk of neoplastic progression. p21 activated kinase 1 (PAK1) mediates 5-ASA activity by orchestrating MAPK signaling, Wnt-β catenin pathway, and cell adhesion; all implicated in the colon carcinogenesis. We evaluated the role of PAK1 in IBD and in colitis-associated cancer (CAC). METHODS AND RESULTS… CONTINUE READING
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Tu1674 PAK1 mediates NF-KB signaling in colitis and colitis-associated cancer

KW Dammann, V Khare, M Lang
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