Overexpression of OATP1B3 confers apoptotic resistance in colon cancer.

  title={Overexpression of OATP1B3 confers apoptotic resistance in colon cancer.},
  author={Wooin Lee and A. Belkhiri and A Craig Lockhart and Nipun B. Merchant and Hartmut Glaeser and Elizabeth I Harris and M. Kay Washington and Elizabeth M. Brunt and Alex I. Zaika and Richard B Kim and Wael El-Rifai},
  journal={Cancer research},
  volume={68 24},
Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative reverse transcription-PCR analysis of 17 colon tumors indicated tumoral overexpression of OATP1B3 by approximately 100-fold, compared with 20 normal colon samples (P < 0.0001). Using immunohistochemistry on a tissue microarray containing 93 evaluable colon tumor specimens, we detected… CONTINUE READING


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An overview of apoptosis and the prevention of colorectal cancer

  • AJ Watson
  • Crit Rev Oncol Hematol
  • 2006
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