Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome.

@article{Siu2008OverexpressionON,
  title={Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome.},
  author={Michelle K. Y. Siu and Esther S. Y. Wong and Hoi Yan Chan and Hextan Yuen-Sheung Ngan and Kelvin Yuen-kwong Chan and Annie Nga-Yin Cheung},
  journal={The American journal of pathology},
  year={2008},
  volume={173 4},
  pages={1165-72}
}
Gestational trophoblastic disease includes choriocarcinoma, a frankly malignant tumor, and hydatidiform mole (HM), which often leads to the development of persistent gestational trophoblastic neoplasia and requires chemotherapy. NANOG is an important transcription factor that is crucial for maintaining embryonic stem cell self-renewal and pluripotency. We postulated that NANOG is involved in the pathogenesis of gestational trophoblastic disease. In this study, significantly higher NANOG mRNA… CONTINUE READING
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