Overexpression of MN1 Confers Resistance to Chemotherapy, Accelerates Leukemia Onset, and Suppresses p53 and Bim Induction

@inproceedings{Pardee2012OverexpressionOM,
  title={Overexpression of MN1 Confers Resistance to Chemotherapy, Accelerates Leukemia Onset, and Suppresses p53 and Bim Induction},
  author={Timothy S Pardee},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND The transcriptional co-activator MN1 confers a worse prognosis for patients with acute myeloid leukemia (AML) when highly expressed; however, the mechanisms involved are unknown. We sought to model the effects of high MN1 expression in AML models to explore the underlying mechanisms. METHODOLOGY/PRINCIPAL FINDINGS We used cell lines and a… CONTINUE READING