Overexpression of MMP-9 correlates with growth of small hepatocellular carcinoma.

@article{Sakamoto2000OverexpressionOM,
  title={Overexpression of MMP-9 correlates with growth of small hepatocellular carcinoma.},
  author={Yuko Sakamoto and Ken-ichi Mafune and Taizou Shiraishi and Hiroshi Imamura and Masaki Mori and Takuya Takayama and Masatoshi Makuuchi},
  journal={International journal of oncology},
  year={2000},
  volume={17 2},
  pages={237-43}
}
Matrix metalloproteinases (MMP) play an important role in tumor cell invasion and metastasis. We examined the expression of MMPs in hepatocellular carcinoma (HCC) to determine whether they may help indicate the progression of HCC and patient outcome. The expression of MMP-1, -2, -7, -9, and MT1-MMP were determined in 37 pairs of HCC and adjacent non-tumor tissue specimens by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). The tumor to non-tumor (T/N) ratios for mRNA… CONTINUE READING