Overexpression of MATH1 disrupts the coordination of neural differentiation in cerebellum development.

@article{Helms2001OverexpressionOM,
  title={Overexpression of MATH1 disrupts the coordination of neural differentiation in cerebellum development.},
  author={Amy W. Helms and Katherine Gowan and Andrew L. Abney and Trisha Savage and Jane E Johnson},
  journal={Molecular and cellular neurosciences},
  year={2001},
  volume={17 4},
  pages={671-82}
}
An essential role for the bHLH transcription factor MATH1 in the formation of cerebellar granule cells was previously demonstrated in a Math1 null mouse. The function of regulated levels of MATH1 in granule cell development is investigated here using a gain-of-function paradigm. Overexpression of Math1 in its normal domain in transgenic mice leads to early postnatal lethality and perturbs cerebellar development. The cerebellum of the (B)MATH1 transgenic neonate is smaller with less foliation… CONTINUE READING

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