Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.

@article{Duan2003OverexpressionOM,
  title={Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.},
  author={Zhenfeng Duan and Yifei Duan and Diana E. Lamendola and Rushdia Zareen Yusuf and Rizwan Naeem and Richard T. Penson and Michael V. Seiden},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 7},
  pages={2778-85}
}
Previous studies directed at identifying paclitaxel resistance genes in a paclitaxel-resistant subclone of the human ovarian cancer cell line SKOV-3 identified a novel cancer testis antigen, Taxol resistance-associated gene 3 (TRAG-3). Because investigation suggested that TRAG-3, located on chromosome Xq28, does not directly participate in the paclitaxel-resistant phenotype, it was hypothesized that TRAG-3 might be linked to a neighboring gene that is directly involved in the drug-resistant… CONTINUE READING