Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.

@article{Bai2000OverexpressionOM,
  title={Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.},
  author={Chang Bai and Bernadette R Connolly and M. L. Metzker and Cathy Hilliard and Xiaodong Liu and Volker Sandig and Avery Soderman and Sheila M. Galloway and Qing Liu and Christopher P. Austin and C. Thomas Caskey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 3},
  pages={1230-5}
}
Fas-mediated apoptosis is an important regulator of cell survival, and abnormalities in this system have been shown to result in a number of human pathological conditions. A secreted member of the tumor necrosis factor receptor superfamily, DcR3, was recently reported to be amplified in human lung and colon cancers as a negative regulator of Fas-mediated apoptosis. We identified this gene, which we call M68. M68 genomic DNA, mRNA, and protein levels were examined in a series of human… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 101 extracted citations

Similar Papers

Loading similar papers…