Overexpression of Large-Conductance Calcium-Activated Potassium Channels in Human Glioblastoma Stem-Like Cells and Their Role in Cell Migration.

@article{Rosa2017OverexpressionOL,
  title={Overexpression of Large-Conductance Calcium-Activated Potassium Channels in Human Glioblastoma Stem-Like Cells and Their Role in Cell Migration.},
  author={Paolo Rosa and Luigi Sforna and Silvia Carlomagno and Giorgio Mangino and Massimo Miscusi and Mauro Pessia and Fabio Franciolini and Antonella Calogero and Luigi Catacuzzeno},
  journal={Journal of cellular physiology},
  year={2017},
  volume={232 9},
  pages={2478-2488}
}
Glioblastomas (GBMs) are brain tumors characterized by diffuse invasion of cancer cells into the healthy brain parenchyma, and establishment of secondary foci. GBM cells abundantly express large-conductance, calcium-activated potassium (BK) channels that are thought to promote cell invasion. Recent evidence suggests that the GBM high invasive potential mainly originates from a pool of stem-like cells, but the expression and function of BK channels in this cell subpopulation have not been… CONTINUE READING