Overexpression of LINC00691 promotes the proliferation and invasion of gastric cancer cells via the Janus kinase/signal transducer and activator of transcription signalling pathway.

  title={Overexpression of LINC00691 promotes the proliferation and invasion of gastric cancer cells via the Janus kinase/signal transducer and activator of transcription signalling pathway.},
  author={W. Liang and Bin Xia and Chao He and Guanghua Zhai and Meifen Li and Jundong Zhou},
  journal={The international journal of biochemistry \& cell biology},

LINC00514 promotes gastric cancer cell growth and EMT progression via miR-204-3p/KRAS

The data indicated that LINC00514 may act as an oncogene and therapeutic target for GC and was upregulated in GC specimens compared with nontumor specimens.

STAM2 knockdown inhibits proliferation, migration, and invasion by affecting the JAK2/STAT3 signaling pathway in gastric cancer.

STAM2 knockdown could suppress malignant process by targeting the JAK2/STAT3 signaling pathway in GC, and was found to significantly inhibit proliferation, block cell cycle, and restrain migration and invasion capabilities of GC cells.

Curcumin Inhibits Papillary Thyroid Cancer Cell Proliferation by Regulating lncRNA LINC00691

Results indicate that curcumin promotes apoptosis and suppresses proliferation and the Warburg effect by inhibiting LINC00691 in B-CPAP cells, providing a theoretical basis for the treatment of PTC withCurcumin.

Skin cutaneous melanoma properties of immune-related lncRNAs identifying potential prognostic biomarkers

A 46 immlncRNA-related prognostic risk score model with excellent predictive efficacy was constructed and provided more possibilities to investigate the immune regulation mechanisms and to develop immunotherapy of SKCM.



LncRNA UCA1 promotes cell proliferation, invasion and migration of laryngeal squamous cell carcinoma cells by activating Wnt/β-catenin signaling pathway

The present findings suggest that UCA1 can promote cell proliferation, invasion and migration of LSCC cells by activating the Wnt/β-catenin signaling pathway.

EGF promotes HIF-1α expression in colorectal cancer cells and tumor metastasis by regulating phosphorylation of STAT3.

  • Fei ZhaoC. Qin
  • Biology
    European review for medical and pharmacological sciences
  • 2019
In SW480 cells, EGF regulated HIF-1α through the STAT3 phosphorylation pathway, eventually promoting the occurrence and metastasis of colorectal cancer.

Long Noncoding RNA FEZF1-AS1 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer by Activation of JAK-STAT3 Pathway

  • Xia ZhaoZ. ChengJian Wang
  • Biology, Medicine
    Medical science monitor : international medical journal of experimental and clinical research
  • 2018
It is demonstrated that FEZF1-AS1 exerted an oncogenic role in ovarian cancer via modulating JAK-STAT3 pathway.

Long noncoding RNA UCA1 promotes the proliferation, invasion, and migration of nasopharyngeal carcinoma cells via modulation of miR-145

This study confirmed that UCA1 was upregulated in NPC cell lines and involved in NPC tumorigenesis according to the established U CA1-associated competing endogenous RNA network, and functional analyses indicated that the downregulation of UCA2 exerted inhibitory effects on cell proliferation, invasion, and migration.

GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling

It is suggested that GRAMD1B is a key signaling molecule that functions to inhibit cell migration in breast cancer by negating both JAK/STAT and Akt signaling, providing the foundation for its development as a novel biomarker in Breast cancer.

Long noncoding RNA UCA1 promotes cell proliferation, migration and invasion of human leukemia cells via sponging miR-126.

This study elucidates a novel UCA1-miR-126-RAC1 regulatory network in ML cells, which may provide the feasibility for use lncRNA-based therapy in AML treatment.

Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA‐128 and modulating MAPK1

Linc00161 regulated the drug resistance of ovarian cancer via modulating microRNA‐128/MAPK1 and inhibited the tumor growth by demonstrated by xenograft tumor model in vivo.

LncRNA UCA1/miR‐124 axis modulates TGFβ1‐induced epithelial‐mesenchymal transition and invasion of tongue cancer cells through JAG1/Notch signaling

A novel mechanism by which the EMT process and cancer cell invasion in tongue cancer could be modulated from the perspective of lncRNA‐miRNA‐mRNA regulation is provided.

LncRNA‐UCA1 modulates progression of colon cancer through regulating the miR‐28‐5p/HOXB3 axis

Evidence is provided for the regulatory network of UCA1/miR‐28‐5p/HOXB3 in colon cancer, suggesting that U CA1, miR‐ 28‐5 p, and HOXB 3 are the potential targets for colon cancer therapy.

M2-like tumor-associated macrophages-secreted EGF promotes epithelial ovarian cancer metastasis via activating EGFR-ERK signaling and suppressing lncRNA LIMT expression

It is demonstrated that EGF secreted by M2-like TAMs might suppress LIMT expression via activating EGFR-ERK signaling pathway to promote the progression of OC.