Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts.

@article{Neuhaus2006OverexpressionOK,
  title={Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts.},
  author={Petra Neuhaus and Benjamin Jaschinsky and Sebastian Schneider and Herbert Neuhaus and Annelies Wolter and Henning Ebelt and Thomas Braun},
  journal={Experimental cell research},
  year={2006},
  volume={312 16},
  pages={3049-59}
}
Targeted migration of muscle precursor cells to the anlagen of limb muscles is a complex process, which is only partially understood. We have used Lbx1 mutant mice, which are unable to establish correct migration paths of muscle precursor cells into the limbs to identify new genes involved in the accurate placement of myogenic cells in developing muscles. We found that mKlhdc2 (Kelch domain containing-2), a novel member of the family of Kelch domain containing proteins, is significantly… CONTINUE READING

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