Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway

@inproceedings{Awwad2015OverexpressionOK,
  title={Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway},
  author={Samah W. Awwad and Nabieh Ayoub},
  booktitle={Biology open},
  year={2015}
}
The KDM4 family of lysine demethylases consists of five members, KDM4A, -B and -C that demethylate H3K9me2/3 and H3K36me2/3 marks, while KDM4D and -E demethylate only H3K9me2/3. Recent studies implicated KDM4 proteins in regulating genomic instability and carcinogenesis. Here, we describe a previously unrecognized pathway by which hyperactivity of KDM4 demethylases promotes genomic instability. We show that overexpression of KDM4A-C, but not KDM4D, disrupts MSH6 foci formation during S phase by… CONTINUE READING