Overexpression of KCNN3 results in sudden cardiac death.

@article{Mahida2014OverexpressionOK,
  title={Overexpression of KCNN3 results in sudden cardiac death.},
  author={Saagar N Mahida and Robert W. Mills and Nathan R Tucker and Bridget Simonson and Vincenzo S. Macri and Marc D. Lemoine and Saumya Das and David J. Milan and Patrick T Ellinor},
  journal={Cardiovascular research},
  year={2014},
  volume={101 2},
  pages={326-34}
}
BACKGROUND A recent genome-wide association study identified a susceptibility locus for atrial fibrillation at the KCNN3 gene. Since the KCNN3 gene encodes for a small conductance calcium-activated potassium channel, we hypothesized that overexpression of the SK3 channel increases susceptibility to cardiac arrhythmias. METHODS AND RESULTS We characterized the cardiac electrophysiological phenotype of a mouse line with overexpression of the SK3 channel. We generated homozygote (SK3(T/T)) and… CONTINUE READING
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