Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.

@article{Engelking2004OverexpressionOI,
  title={Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.},
  author={Luke J Engelking and Hiroshi Kuriyama and Robert Hammer and Jay D. Horton and Michael Scott Brown and Joseph L Goldstein and Guosheng Liang},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 8},
  pages={1168-75}
}
In the current studies we generated transgenic mice that overexpress human Insig-1 in the liver under a constitutive promoter. In cultured cells Insig-1 and Insig-2 have been shown to block lipid synthesis in a cholesterol-dependent fashion by inhibiting proteolytic processing of sterol regulatory element-binding proteins (SREBPs), membrane-bound… CONTINUE READING