Overexpression of IL-4 alters the homeostasis in the skin.

  title={Overexpression of IL-4 alters the homeostasis in the skin.},
  author={Adelheid Elbe-B{\"u}rger and Alena Egyed and Sabine Olt and Radek Klubal and Ulrike Mann and Klemens Rappersberger and Antal Rot and Georg Stingl},
  journal={The Journal of investigative dermatology},
  volume={118 5},
IL-4 has been implicated to play an important role in the pathogenesis of many inflammatory diseases including skin diseases such as atopic dermatitis. Because it is not clear which pathologic features of atopic dermatitis are dependent on IL-4, we assessed the consequences of IL-4 overexpression in the skin, using transgenic mice overexpressing IL-4 ubiquitously. Although transgenic mice display no clinical signs of skin inflammation, IL-4 induced a wide spectrum of pathologies including an… CONTINUE READING


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