Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

@article{Barreyro2012OverexpressionOI,
  title={Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.},
  author={Laura Barreyro and Britta Will and Boris Bartholdy and Li Zhou and Tihomira I Todorova and Robert F Stanley and Susana Ben-Neriah and Cristina Montagna and S. Parekh and Andrea Pellagatti and Jacqueline Boultwood and Elisabeth Paietta and Rhett P. Ketterling and Larry Dean Cripe and Hugo F Fernandez and Peter L. Greenberg and Martin S. Tallman and Christian Steidl and Constantine Mitsiades and Amit Verma and Ulrich Steidl},
  journal={Blood},
  year={2012},
  volume={120 6},
  pages={1290-8}
}
Cellular and interpatient heterogeneity and the involvement of different stem and progenitor compartments in leukemogenesis are challenges for the identification of common pathways contributing to the initiation and maintenance of acute myeloid leukemia (AML). Here we used a strategy of parallel transcriptional analysis of phenotypic long-term hematopoietic stem cells (HSCs), short-term HSCs, and granulocyte-monocyte progenitors from individuals with high-risk (-7/7q-) AML and compared them… CONTINUE READING

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