Overexpression of Heme Oxygenase-1 Prevents Renal Interstitial Inflammation and Fibrosis Induced by Unilateral Ureter Obstruction.

@article{Chen2016OverexpressionOH,
  title={Overexpression of Heme Oxygenase-1 Prevents Renal Interstitial Inflammation and Fibrosis Induced by Unilateral Ureter Obstruction.},
  author={Xiao Chen and Shi-Yao Wei and Jian-Si Li and Qing-Fang Zhang and Yu-Xiao Wang and Shi-lei Zhao and Jing Yu and Chang Cheng Wang and Ying Qin and Qiu-Ju Wei and Gui-xiang Lv and Bing Nan Li},
  journal={PloS one},
  year={2016},
  volume={11 1},
  pages={e0147084}
}
Renal fibrosis plays an important role in the onset and progression of chronic kidney diseases. Many studies have demonstrated that heme oxygenase-1 (HO-1) is involved in diverse biological processes as a cytoprotective molecule, including anti-inflammatory, anti-oxidant, anti-apoptotic, antiproliferative, and immunomodulatory effects. However, the mechanisms of HO-1 prevention in renal interstitial fibrosis remain unknown. In this study, HO-1 transgenic (TG) mice were employed to investigate… CONTINUE READING
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