Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation

@article{Kovacsovics2002OverexpressionOH,
  title={Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation},
  author={Magdalena Kovacsovics and Fabio Martinon and Olivier Micheau and J L Bodmer and Kay Hofmann and Jürg Tschopp},
  journal={Current Biology},
  year={2002},
  volume={12}
}
Apoptotic cell death is characterized by several morphological nuclear changes, such as chromatin condensation and extensive fragmentation of chromosomal DNA. These alterations are primarily triggered through the activation of caspases, which subsequently cleave nuclear substrates. Caspase-3 induces processing of Acinus, which leads to chromatin condensation. DNA fragmentation is dependent on the DNase CAD, which is released from its inhibitor, ICAD, upon cleavage by caspase-3. DNA degradation… 
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