Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age-related muscle dysfunction.

Abstract

Ageing is associated with skeletal muscle atrophy, a deficit in force generation, an increased susceptibility to contraction-induced injury, and a permanent force deficit following severe injury. Muscles of young mice adapt rapidly following exercise by an increase in the production of heat shock proteins (HSPs), whereas muscles of old mice show a severely… (More)

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@article{McArdle2004OverexpressionOH, title={Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age-related muscle dysfunction.}, author={Anne McArdle and Wolfgang H. Dillmann and Ruben Mestril and John A. Faulkner and M. J. Jackson}, journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year={2004}, volume={18 2}, pages={355-7} }