Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclase.

@article{Marcil1998OverexpressionOG,
  title={Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclase.},
  author={Jos{\'e}e Marcil and Jacques de Champlain and Madhu B Anand-Srivastava},
  journal={Cardiovascular research},
  year={1998},
  volume={39 2},
  pages={492-505}
}
OBJECTIVE In the present studies, we have investigated if aorta, like heart from deoxycorticosterone acetate (DOCA)-salt hypertensive rats, (HR) also exhibit enhanced expression of G-protein levels and if these alterations occur before or after the development of blood pressure. METHODS Sprague-Dawley rats treated with DOCA-salt or vehicle for 1, 2, 3 and 4 weeks were used for these studies. The levels of inhibitory guanine nucleotide regulatory proteins (Gi alpha-2, Gi alpha-3) and G beta… CONTINUE READING

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