Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.

  title={Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.},
  author={Hiroyuki Takahashi and Jianping Wang and Hua-Chuan Zheng and Shinji Masuda and Yasuo Takano},
  journal={Histology and histopathology},
  volume={26 6},
Glucose-related proteins (GRPs) are ubiquitously expressed in the endoplasmic reticulum and assist in protein folding and assembly, consequently considered to be molecular chaperones. GRP78 and GRP94 expression was induced by glucose starvation and up-regulated in samples taken from several different malignant tissues. To clarify the roles of both molecules in tumorigenesis and progression of colorectal carcinomas, immunohistochemistry (IHC) was performed on tissue microarrays containing… CONTINUE READING
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