Overexpression of GD1a ganglioside sensitizes motor nerve terminals to anti-GD1a antibody-mediated injury in a model of acute motor axonal neuropathy.

@article{Goodfellow2005OverexpressionOG,
  title={Overexpression of GD1a ganglioside sensitizes motor nerve terminals to anti-GD1a antibody-mediated injury in a model of acute motor axonal neuropathy.},
  author={John Aaron Goodfellow and Tyrone V. Bowes and Kazim A Sheikh and Masaaki Odaka and Susan K. Halstead and Peter D. Humphreys and Eric R. Wagner and Nobuhiro Yuki and Koichi Furukawa and Jaap J. Plomp and Hugh John Willison},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 7},
  pages={1620-8}
}
Anti-GD1a ganglioside antibodies (Abs) are the serological hallmark of the acute motor axonal form of the post-infectious paralysis, Guillain-Barre syndrome. Development of a disease model in mice has been impeded by the weak immunogenicity of gangliosides and the apparent resistance of GD1a-containing neural membranes to anti-GD1a antibody-mediated injury. Here we used mice with altered ganglioside biosynthesis to generate such a model at motor nerve terminals. First, we bypassed immunological… CONTINUE READING