Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities

@article{Vicente2012OverexpressionOG,
  title={Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities},
  author={Cor{\'a}lia Vicente and Iria V{\'a}zquez and Ana Conchillo and M. A. Garc{\'i}a-S{\'a}nchez and Nerea Marcotegui and Oscar Fuster and M de L Gonzalez and Mar{\'i}a Jos{\'e} Calasanz and Idoya Lahortiga and Mar{\'i}a Dolores Odero},
  journal={Leukemia},
  year={2012},
  volume={26},
  pages={550-554}
}
Acute myeloid leukemia (AML) represents a heterogeneous group of hematological neoplasms associated with the accumulation of acquired genetic and epigenetic aberrations in hematopoietic progenitor cells. Myeloid leukemogenesis is directly linked to the disruption of expression of transcription factors that regulate the proliferation, survival and differentiation of myeloid progenitors. Moreover, overexpression of particular genes has been associated with prognosis in AML, enabling patients with… CONTINUE READING

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