Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells.

@article{Zook2011OverexpressionOF,
  title={Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells.},
  author={Erin Christine Zook and Paulette A. Krishack and Shubin Zhang and Nancy J. Zeleznik-Le and Anthony B. Firulli and Pamela L. Witte and Phong T. Le},
  journal={Blood},
  year={2011},
  volume={118 22},
  pages={5723-31}
}
The forkhead box n1 (Foxn1) transcription factor is essential for thymic organogenesis during embryonic development; however, a functional role of Foxn1 in the postnatal thymus is less well understood. We developed Foxn1 transgenic mice (Foxn1Tg), in which overexpression of Foxn1 is driven by the human keratin-14 promoter. Expression of the Foxn1 transgene increased the endogenous Foxn1 levels. In aged mice, overexpression of Foxn1 in the thymus attenuated the decline in thymocyte numbers… CONTINUE READING
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