Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome.

@article{Huang2011OverexpressionOF,
  title={Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome.},
  author={Mingguo Huang and Shintaro Narita and Norihiko Tsuchiya and Zhiyong Ma and Kazuyuki Numakura and Takashi Obara and Hiroshi Tsuruta and Mitsuru Saito and Takamitsu Inoue and Yohei Horikawa and Shigeru Satoh and Tomonori Habuchi},
  journal={Carcinogenesis},
  year={2011},
  volume={32 11},
  pages={1589-96}
}
Fibroblast growth factor-inducible 14 (Fn14), a transmembrane receptor binding to the multifunctional cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK), is known to modulate many cellular activities including cancer progression. Here, we demonstrated the significant role of Fn14 in invasion, migration and proliferation of androgen-independent prostate cancer (AIPC) cells. Fn14 and its ligand TWEAK were highly expressed in two AIPC cell lines, DU 145 and PC-3, whereas… CONTINUE READING
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