Overexpression of Essential Splicing Factor ASF/SF2 Blocks the Temporal Shift in Adenovirus Pre-mRNA Splicing and Reduces Virus Progeny Formation

@article{Molin2000OverexpressionOE,
  title={Overexpression of Essential Splicing Factor ASF/SF2 Blocks the Temporal Shift in Adenovirus Pre-mRNA Splicing and Reduces Virus Progeny Formation},
  author={M. Molin and G. Akusj{\"a}rvi},
  journal={Journal of Virology},
  year={2000},
  volume={74},
  pages={9002 - 9009}
}
  • M. Molin, G. Akusjärvi
  • Published 2000
  • Biology, Medicine
  • Journal of Virology
  • ABSTRACT Expression of cytoplasmic mRNA from most adenovirus transcription units is subjected to a temporal regulation at the level of alternative pre-mRNA splicing. The general tendency is that splice site selection changes from proximal to distal late after infection. Interestingly, ASF/SF2, which is a prototypical member of the SR family of splicing factors, has the opposite effect on splice site selection, inducing an increase in proximal splice site usage. We have previously shown that SR… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 47 REFERENCES
    Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.
    188
    Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA
    273
    Defective RNA splicing in the absence of adenovirus-associated RNAI.
    15
    Control of 3' splice site choice in vivo by ASF/SF2 and hnRNP A1.
    74