Overexpression of Endoglin Modulates TGF-β1-Signalling Pathways in a Novel Immortalized Mouse Hepatic Stellate Cell Line

@inproceedings{Meurer2013OverexpressionOE,
  title={Overexpression of Endoglin Modulates TGF-β1-Signalling Pathways in a Novel Immortalized Mouse Hepatic Stellate Cell Line},
  author={Steffen Meurer and Muhammad Alsamman and Hacer Sahin and Hermann Elard Wasmuth and Tatiana Kisseleva and David Brenner and Francisco Javier Cubero and Ralf Weiskirchen and David Scholten},
  booktitle={PloS one},
  year={2013}
}
Hepatic stellate cells (HSCs) play a major role in the pathogenesis of liver fibrosis. Working on primary HSCs requires difficult isolation procedures; therefore we have generated and here characterize a mouse hepatic stellate cell line expressing GFP under control of the collagen 1(I) promoter/enhancer. These cells are responsive to pro-fibrogenic stimuIi, such as PDGF or TGF-β1, and are able to activate intracellular signalling pathways including Smads and MAP kinases. Nevertheless, due to… CONTINUE READING
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