Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene.

@article{Dsouza1994OverexpressionOE,
  title={Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene.},
  author={B D'souza and Joyce Taylor-Papadimitriou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 15},
  pages={
          7202-6
        }
}
Overexpression of the ERBB2 receptor in transfectants of a human mammary epithelial cell line (MTSV1-7) is associated with a reduced ability to undergo morphogenesis in vitro and with a decreased level of expression of the E-cadherin and alpha 2 integrin genes. The inhibition of expression of the adhesion molecules has been shown to be at the level of transcription by using nuclear run-on assays and by following transcription of a reporter gene fused to 5' sequences of the E-cadherin gene. To… CONTINUE READING

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