Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition.

@article{Zhu2012OverexpressionOE,
  title={Overexpression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition.},
  author={Wei Zhu and Mu-Yan Cai and Zhu-Ting Tong and Sui-sui Dong and S J Mai and Yi-ji Liao and Xiu-Wu Bian and Marie C. M. Lin and Hsiang-fu Kung and Yi-xin Zeng and Xinyuan Guan and Dan Xie},
  journal={Gut},
  year={2012},
  volume={61 4},
  pages={562-75}
}
BACKGROUND AND AIMS The authors have previously isolated a putative oncogene, eukaryotic initiation factor 5A2 (EIF5A2) from 3q26. In this study, EIF5A2 was characterised for its role in colorectal carcinoma (CRC) aggressiveness and underlying molecular mechanisms. METHODS The expression dynamics of EIF5A2 were examined by immunohistochemistry in a cohort of carcinomatous and non-neoplastic colorectal tissues and cells. A series of in-vivo and in-vitro assays was performed to elucidate the… CONTINUE READING
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