Overexpression of E2F‐1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

Abstract

The transfer of apoptosis genes to tumors is one of the most promising strategies for cancer gene therapy. We have shown that massive apoptosis occurs when wild-type p53 expression is induced in glioma cells carrying a p53 gene mutation. However, adenovirus-mediated p53 gene transfer is ineffective in causing apoptosis in glioma cells that retain a wild… (More)
DOI: 10.1038/nm0698-685

Topics

Cite this paper

@article{Fueyo1998OverexpressionOE, title={Overexpression of E2F‐1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo}, author={Juan Fueyo and Candeleria Gomez-Manzano and W. K. Alfred Yung and T. J. Liu and Ramon Alemany and T. J. McDonnell and X. Shi and Jasti S. Rao and V. A. Levin and Athanassios P. Kyritsis}, journal={Nature Medicine}, year={1998}, volume={4}, pages={685-690} }