Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA.

@article{MolinaOrtiz2009OverexpressionOE,
  title={Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA.},
  author={Isabel Molina-Ortiz and Ruben A. Bartolom{\'e} and Pablo Hern{\'a}ndez-Varas and Georgina P Col{\'o} and Joaqu{\'i}n Teixid{\'o}},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 22},
  pages={15147-57}
}
Melanoma cells express the chemokine receptor CXCR4 that confers high invasiveness upon binding to its ligand CXCL12. Melanoma cells at initial stages of the disease show reduction or loss of E-cadherin expression, but recovery of its expression is frequently found at advanced phases. We overexpressed E-cadherin in the highly invasive BRO lung metastatic cell melanoma cell line to investigate whether it could influence CXCL12-promoted cell invasion. Overexpression of E-cadherin led to defective… CONTINUE READING

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