Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells.

@article{Venturelli1995OverexpressionOD,
  title={Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells.},
  author={D. Venturelli and Robert V. Martinez and Paola Melotti and Ida Casella and Cesare Peschle and Carla Cucco and G C Spampinato and Zbigniew Darzynkiewicz and Bruno Calabretta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 16},
  pages={7435-9}
}
Chronic myelogenous leukemia evolves in two clinically distinct stages: a chronic and a blast crisis phase. The molecular changes associated with chronic phase to blast crisis transition are largely unknown. We have identified a cDNA clone, DR-nm23, differentially expressed in a blast-crisis cDNA library, which has approximately 70% sequence similarity to the putative metastatic suppressor genes, nm23-H1 and nm23-H2. The deduced amino acid sequence similarity to the proteins encoded by these… CONTINUE READING
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